Go to our "CLOSINGS" tab on our website to see our updated Coronavirus Policy

Category Archives: UNCATEGORIZED

SMART Asthma Therapy

Asthma is a chronic inflammatory disease of the airways that causes frequent symptoms of coughing, chest tightness, wheezing and/or shortness of breath.

If the symptoms are less frequent than twice a week during the daytime and less than twice a month during the nights, it is termed “intermittent” asthma. If the symptoms are more frequent than twice a week during the daytime and more than twice a month during the nights, it is called “persistent” asthma. Persistent asthma is further subdivided into mild, moderate, and severe based on the severity and frequency of the asthma symptoms as well as lung function measurements obtained by pulmonary function tests.

Intermittent asthma is traditionally treated with an as needed “rescue” inhaler medication, which is usually an albuterol (e.g., ProAir, Proventil, Ventolin) inhaler. Albuterol is a short-acting beta 2 agonist bronchodilator medication which acts as a dilator of the bronchial tubes of the lungs. It provides quick relief for the wheezing, chest tightness, coughing, and shortness of breath that plagues asthma sufferers. The usual dose is 2 puffs from the inhaler every 4 to 6 hours as needed for symptom relief. Albuterol can also be used prior to exertion for the prevention of exercise-induced asthma symptoms.

Persistent asthma, on the other hand, needs a daily scheduled maintenance medication in order to control the inflammation that occurs in asthmatics. The daily maintenance medication helps prevent symptoms and preserve the lung function in the long term. The maintenance medication usually consists of a corticosteroid in the form of an inhaler [Flovent (fluticasone), QVAR Redihaler (beclomethasone), Asmanex (mometasone), Pulmicort (budesonide), Arnuity (fluticasone), Alvesco (ciclesonide), Aerobid (flunisolide)] which is usually taken either once or twice a day. There is also another maintenance therapy that does not include a corticosteroid. Such non-steroid maintenance medications typically are known as leukotriene antagonists [e.g., Singulair (montelukast), Accolate (zafirlukast), Zyflo (zileuton)]. It is up to the allergist and patient to decide which type of maintenance therapy is best for that patient.

Since a maintenance medication is needed in most persistent asthmatic patients, usually 2 different types of inhalers are needed in total – one for the daily preventive maintenance and the other for the as needed quick relief for asthma symptoms. Though it is an effective way of treating asthma, it can sometimes lead to confusion for some patients, so it is necessary for the board certified allergist to explain how and when to use both types of medications.

There has been a recent update in the recommendations for asthma management from the National Asthma Education and Prevention Program. The newer guidelines recommend one inhaler both for prevention and rescue therapy. This new recommendation is termed Single Maintenance And Reliever Therapy (SMART).

The recommended inhaler contains a combination of a corticosteroid (anti-inflammatory agent) and a short-acting beta 2 agonist bronchodilator to open the airways quickly. In addition to using it once or twice a day on a regular daily basis for maintenance, the patient can take one or two puffs from the same inhaler as needed for the rapid relief of the symptoms. SMART therapy is approved for children who are 5 years old and above.

Clinical studies have shown that SMART therapy reduces acute flare-ups, emergency healthcare visits, and hospitalizations compared to the traditional therapy in patients with moderate and severe persistent asthma. However, If the patient’s current therapy is controlling their asthma well and they are not having side effects, there is no need to make a change.

There are 2 main corticosteroid medications recommended for SMART therapy: budesonide and mometasone. These 2 corticosteroids can be used as the preventive component. Formoterol is a faster acting long-acting beta 2 agonist that is used as the rescue component. Only formoterol-containing formulations should be used. Formoterol has a more rapid onset bronchodilator effect than other long-acting beta 2 agonists, similar to albuterol. Budesonide/formoterol (i.e., Symbicort) is the most commonly used formulation for SMART therapy, but mometasone/formoterol (i.e., Dulera) may also be used.

The board certified allergy specialists at Black & Kletz Allergy have been treating asthma in pediatric and adult patients for more than 5 decades. We have 3 offices in the Washington, DC, Northern Virginia, and Maryland metropolitan area which are located in Washington, DC, McLean, VA (Tysons Corner, VA), and Manassas, VA. All 3 offices have on-site parking and the Washington, DC and McLean, VA offices are Metro accessible. There is a free shuttle that runs between our McLean, VA office and the Spring Hill metro station on the silver line. If you or someone you know has asthma or any other allergic or immunologic condition, please make an appointment so that we may help you. Alternatively, you can click Request an Appointment and we will respond to your request within 24 hours by the next business day. The allergy doctors at Black & Kletz Allergy have been treating patients in the Washington, DC metropolitan area for allergies, asthma, sinus disease, and immunologic disorders for more than 50 years. We would be pleased to provide allergy and asthma relief for you and your family in a relaxed, caring, and professional environment.

Hives, Itching, and Swelling

Of all the ailments that people seek an allergist’s care for, one of the most bothersome conditions is hives (i.e., urticaria). A hive can be described as an itchy red blotch or welt that can occur anywhere on the skin. A hive can be flush with the skin or it can be a raised bump. Usually, there are a multitude of hives that occur as opposed to just one hive, although a single hive may occur. The size and shape of a hive is variable as it can be large or small and it can take any shape. Although hives usually itch, they can occur without itching. Hives can also occur internally such as the gastrointestinal system. If the hives occur in the stomach, the individual may experience abdominal pain, abdominal cramping, nausea, and/or vomiting as a result of internal hives. If the hives occur in the throat, the person may feel a tightening of their throat.

There are 2 basic criteria for hives. If one has hives on and off for less than 6 weeks, that person is said to have “acute” urticaria. If, however, the hives last 6 or more weeks, that individual is said to have “chronic” urticaria. Acute urticaria is more common than chronic urticaria and it is not uncommon. Approximately 20-25% of Americans will have hives at some point in their lives. Hives generally last less than 24 hours, but may last longer. They may occur very frequently (i.e., multiple times a day) or occur very rarely, (i.e., one isolated episode). Hives tend to be intermittent (i.e., come and go) as opposed to remaining on the skin for days, weeks, or months like eczema (i.e., atopic dermatitis). Chronic urticaria acts the same as acute urticaria except that the duration of the hives is 6 weeks or greater.

There are many causes of hives. Some of the common causes of hives may include an allergy to a food (e.g., peanuts, tree nuts, milk, egg, soy, wheat, fish, shellfish), medication [e.g., antibiotic, aspirin, nonsteroidal anti-inflammatory drugs (ibuprofen (Advil, Motrin), naproxen (Naprosyn, Aleve, Anaprox), indomethacin (Indocin), salsalate (Disalcid), diclofenac (Arthrotec, Voltaren, Cataflam), ketorolac (Toradol), celecoxib (Celebrex), meloxicam (Mobic), nabumetone (Relafen), tolmetin (Tolectin), fenoprofen (Asaid), etodolac (Lodine), sulindac (Clinoril), piroxicam (Feldene), and oxaprozin (Daypro)], or flying insect sting (e.g., bee sting). Other common causes may include an infection (i.e., viral, bacterial, fungal, or parasitic), autoimmune disorders (i.e., the immune system fights against an individual’s body instead of fighting against outside invaders), inflammatory conditions (i.e., vasculitis), and/or rarely cancers. In addition to the forementioned causes, physical stimuli such as heat, cold, exercise, pressure, vibration, sun exposure, and/or even water exposure can cause hives in sensitive individuals.

If someone has chronic urticaria, it is important to find out if there is an underlying condition present that is causing that individual to have the hives. The diagnosis of hives begins with a comprehensive history and physical examination. Allergy skin testing or blood testing may be needed depending on the patient’s unique situation with respect to their hives. For patients with chronic urticaria, blood testing and a urinalysis are obtained in order to look for an underlying condition that may be causing the hives. It is interesting to note that despite doing a thorough workup for chronic urticaria with blood and urine tests, 95% of the time no cause is identified. In these cases, the chronic urticaria is designated as “idiopathic” which is basically saying that we know what is not causing the hives, but we still do not know what is causing them. These patients are labeled as having chronic idiopathic urticaria (CIU) or chronic spontaneous urticaria (CSU).

The treatment of hives usually begins with oral antihistamines or H1 blockers [e.g., Claritin (loratadine), Allegra (fexofenadine), Zyrtec (cetirizine), Xyzal (levocetirizine)]. In some cases, H2 blockers such as Pepcid (famotidine) may be used in combination with the H1 blocker (antihistamine). Leukotriene antagonists [e.g., Singulair (monteleukast)] may also be used if needed. Occasionally corticosteroids may be necessary to treat recalcitrant cases. In addition to the above medications, patients with chronic spontaneous urticaria (i.e., chronic idiopathic urticaria) may benefit greatly with Xolair (omalizumab), a biologic injectable medication which is usually administered monthly.

There are 2 other conditions that are related to hives that should be discussed since they can occur without hives or with hives. They are as follows:

Pruritus: Even though pruritus technically means “to itch,” it should be noted that some individuals just itch without having associated hives while as mentioned above, some itch with associated hives. For the purposes of this blog, pruritus means the former, itching without hives or a rash. The diagnosis and management are essentially the same as with hives except Xolair is not used in patients with just pruritus alone.

Swelling (i.e., angioedema): Similar to pruritus, swelling (i.e., angioedema) may occur simultaneously with hives or the swelling can occur without associated hives. One can think of angioedema as a large hive, so in essence it is not really different from a hive, except it can be scarier to the individual with the swelling. Of course if the swelling is in the throat for example, it can be life-threatening. The diagnosis and treatment are also basically the same as with hives except there is an added blood test (i.e., C1 esterase inhibitor level) that is obtained and like with the treatment of pruritus, Xolair is not used with just angioedema alone.

The board certified allergy doctors at Black & Kletz Allergy located in the Washington, DC, Northern Virginia, and Maryland metropolitan area will readily answer any questions you have regarding hives (i.e., urticarial), itching (i.e., pruritus), swelling (i.e., angioedema) or any other allergic condition. We have 3 offices with locations in Washington, DC, McLean, VA (Tysons Corner, VA), and Manassas, VA. All of our offices offer on-site parking. In addition, the Washington, DC and McLean, VA offices are accessible by Metro. There is also a free shuttle that runs between the McLean, VA office and the Spring Hill metro station on the silver line. Please make an appointment by calling any one of our 3 offices, or alternatively, you can click Request an Appointment and we will answer you within 24 hours by the next business day. Black & Kletz Allergy diagnoses and treats both children and adults and we are proud to serve the Washington, DC metro area residents for which we have done for more than 5 decades.

New Treatments for Eosinophilic Esophagitis

The esophagus is the muscular tube that propels food from the mouth into the stomach through a rhythmic, coordinated peristaltic action. The interior lumen of the tube is covered by a thin mucus membrane. This normal function can be impaired when the structure is chronically inflamed by various allergic triggers. A subset of white blood cells, called eosinophils, accumulate in the mucus membrane of the esophagus in response to the exposure of allergens that an individual is sensitized to. These eosinophils will release a number of chemical mediators of inflammation into the tissues causing structural and functional damage. When this occurs, the individual has a condition called eosinophilic esophagitis (EoE).

Eosinophilic esophagitis is a relatively newly recognized condition. It has been increasingly diagnosed in adults and children over the past couple of decades. The frequency of eosinophilic esophagitis has been estimated to be approximately 1 in 2,000 individuals.

Food allergens are the most common cause of eosinophilic esophagitis. Though any food can be an allergen in theory, the most commonly implicated foods in patients with eosinophilic esophagitis are milk, wheat, soy, eggs, peanuts, tree nuts, and fish/shellfish. Individuals with eosinophilic esophagitis often have other allergic diseases such as allergic rhinitis (i.e., hay fever), asthma and/or eczema (i.e., atopic dermatitis).

Genetic factors play a role in the causation of eosinophilic esophagitis as the condition is known to run in families. Some individuals with this condition have been found to have an unusually high expression of a particular gene named eotaxin-3.

SYMPTOMS:

The symptoms of eosinophilic esophagitis ay vary by the age of the patient as well as the severity of the inflammation. The main symptoms are listed below:

  • Difficulty swallowing (i.e., dysphagia)
  • Food getting stuck in the throat (impaction)
  • Nausea/vomiting
  • Abdominal pain
  • Poor appetite/weight loss

DIAGNOSIS:

The diagnosis is often delayed because of a lack of awareness of this condition. A high index of suspicion is needed for the detection of eosinophilic esophagitis in both children and adults presenting with above symptoms.

In order to confirm the diagnosis of eosinophilic esophagitis, it is necessary to do an upper endoscopy, where a thin flexible tube with a light source is passed into the esophagus through the mouth in order to visualize the esophagus. The appearance of whitish patches (i.e., plaques), furrows, and in late stages, circular rings resulting from scarring, are highly suggestive of eosinophilic esophagitis. Multiple biopsies are needed of the inner esophagus during this procedure. The diagnosis is conclusively established by the demonstration of the excessive accumulation of eosinophils in the biopsy specimens obtained from the esophagus.

Environmental allergies to substances such as pollens, animals, dust mites, and molds possibly play a role in eosinophilic esophagitis. For some patients, it may seem like their eosinophilic esophagitis is worse during pollen seasons. Allergy testing for these common environmental allergens is often part of an eosinophilic esophagitis evaluation.

TREATMENT:

The treatment of eosinophilic esophagitis involves a variety of approaches:

1. Dietary Modifications:

  • 6 food (i.e., diary, egg, wheat, soy, nuts, seafood) elimination diet
  • Elimination of foods based on allergy skin prick and/or patch testing
  • Elemental (i.e., amino acid) diet

If the symptoms improve while on dietary restriction, foods can be gradually be reintroduced, one food at a time, while closely monitoring for the relapse of symptoms.

2. Drug Therapy:

  • Proton pump inhibitors (e.g., Prilosec, Nexium) improve symptoms in a subset of patients either by reducing the excessive acid production or more likely by a direct anti-inflammatory action over the esophagus.
  • Topical inhaled corticosteroid medications such as fluticasone (i.e., Flovent) and budesonide (i.e., Pulmicort). These are approved only as inhaled anti-inflammatory agents for asthma, but are used off-label as ingestible medications for eosinophilic esophagitis. These medications coat the mucus membrane, reduce the eosinophilic inflammation, and lead to symptom improvement.
  • Additional endoscopies and biopsies are usually necessary to monitor the effectiveness of treatment.

3. Biological Medications:

In 2022, dupilumab (i.e., Dupixent) was approved by the U.S. Food and Drug Administration (FDA) to treat adults and children 12 years and older with eosinophilic esophagitis. This is the first FDA-approved treatment for eosinophilic esophagitis.

Dupixent is administered by injection under the skin once a week. This medication reduces the number of eosinophils in the esophagus and can lead to significant relief from symptoms.

SUPPORT:

Families often benefit from participating in support groups and organizations. The American Partnership for Eosinophilic Disorders (APFED) and Campaign Urging Research for Eosinophilic Disease (CURED) are two lay organizations that provide valuable reliable resources for individuals with eosinophilic esophagitis.

The board certified allergy doctors at Black & Kletz Allergy have been diagnosing and treating eosinophilic esophagitis in both adults and children in patients in the Washington, DC, Northern Virginia, and Maryland metropolitan area for many years. Black & Kletz Allergy has 3 offices in the Washington, DC metro area with locations in Washington, DC, McLean, VA (Tysons Corner, VA), and Manassas, VA. All of our offices have on-site parking and the Washington, DC and McLean, VA offices are Metro accessible. We offer a free shuttle that runs between our McLean, VA office and the Spring Hill metro station on the silver line. If you suffer from difficulty swallowing, food getting stuck in your throat, or any other symptom related to eosinophilic esophagitis, please call us to make an appointment at one of our conveniently located offices. Alternatively, you may click Request an Appointment and we will respond within 24 hours by the next business day. The allergists at Black & Kletz Allergy are confident that we will be able to help you get to the bottom of your problem as well as treat this gastrointestinal disorder. We have been serving the Washington, DC metro area for more than 50 years in the field of allergy, asthma, and immunology and we hope to improve your quality of life by reducing or preventing your unwanted and bothersome allergy symptoms.

Pollen Food Allergy Syndrome

Pollen Food Allergy Syndrome (also called pollen food allergy syndrome) is a condition where there is a cross reaction to allergens that are found both in pollen and certain foods. The most common foods associated with pollen food allergy syndrome include fresh fruits, vegetables, and some tree nuts. The disorder affects roughly one-third of individuals with seasonal allergic rhinitis (i.e., hay fever).

The primary inner workings of pollen food allergy syndrome is a genetically determined “sensitization” of the immune system to various pollens and the ensuing “reactions” when exposed to these pollens. The immune system sees these pollens as “foreign” and consequently reacts against them resulting in the irritating symptoms of hay fever. The immune system recognizes the pollen as well as similar proteins in the food and then subsequently directs an allergic response to the allergenic protein. An easy way to think of it is that your body sees the food as the pollen since the allergenic proteins of the food is very similar to the allergenic proteins of the pollen. If you are allergic to a pollen such as birch tree pollen, you will then mount an allergic response to a cross-reacting food such as a raw fresh apple even though you are not allergic to that food (i.e., apple) because your body normally mounts a response to that birch tree pollen. It is important to note that in most instances, the person can eat the food if it is cooked (i.e., baked apple) without allergic symptoms. The reason individuals can usually eat the cooked version of the food is because the heating process changes the structure of the protein of the food so it looks different structurally. This structurally changed food protein is not recognized by the immune system as a protein that is similar to the pollen, and thus no allergic reaction occurs.

The symptoms of pollen food allergy syndrome may include itching of the lips, tongue, gums, palate and/or throat after eating raw fresh fruits, vegetables, and/or some tree nuts (i.e., almond, hazelnut). The symptoms usually start within a few minutes after eating the raw fresh fruits, vegetables, and/or tree nut and generally abates within a few hours. The symptoms of pollen food allergy syndrome are usually minimal, but in rare cases, they can cause throat swelling and/or difficulty in swallowing. Such severe reactions are more likely to occur with peanuts and/or tree nuts. It is important to establish that some people with itchy lips, mouth and/or throat after eating a raw fresh specific fruit, vegetable, and/or tree nut may in fact have a true food allergy to a specific fruit, vegetable and/or tree nut and not have pollen food allergy syndrome. These “real” food-allergic individuals usually will have the same or comparable symptoms even when eating the fruit/vegetable cooked, unlike patients with pollen food allergy syndrome who can usually tolerate the cooked fruit/vegetable without symptoms.

Pollen food allergy syndrome tends to be more prominent and bothersome in the Spring months when one is exposed to higher levels of pollen. Specific tree pollen sensitivity cross-reacts with specific fruit/vegetable/tree nut proteins due to the closeness in the amino acid sequences of the allergenic proteins. For example, patients with birch pollen sensitivity tend to react more commonly with fresh raw pitted fruits (e.g., apples, peaches, pears, apricots, plums) as well as carrots, peanuts, and/or tree nuts. Individuals with allergies to grasses may have a reaction to celery, peaches, melons, (e.g., watermelon, honeydew, cantaloupe), oranges, and tomatoes. Ragweed pollen sensitivity in the Fall usually cross-reacts with bananas, melons, cucumbers, and/or zucchini.

The diagnosis of pollen food allergy syndrome is made commonly by a history of oral pruritus (i.e., itching) and irritation in individuals who have previously tested positive for allergies to pollen and are symptomatic during the corresponding pollen seasons.

The treatment of pollen food allergy syndrome involves evading the offending raw fresh fruits/vegetables/tree nut. Peeling the skin before eating and/or cooking (i.e., baking, microwaving) before eating the food may reduce the severity of the symptoms, as heat denatures the allergenic protein which thus decreases its allergenic potential.

The board certified allergy doctors at Black & Kletz Allergy have expertise in diagnosing and treating pollen food allergy syndrome as well as food allergies. . We are board certified to diagnose and treat both adult and pediatric patients and we have been doing so in the Washington, DC, Northern Virginia, and Maryland metropolitan area for more than a half a century. Black & Kletz Allergy has offices in Washington, DC, McLean, VA (Tysons Corner, VA), and Manassas, VA. All 3 of our offices have on-site parking. For additional convenience, our Washington, DC and McLean, VA offices are Metro accessible. Our McLean office location offers a complementary shuttle that runs between our office and the Spring Hill metro station on the silver line. For an appointment, please call our office or alternatively, you can click Request an Appointment and we will respond within 24 hours by the next business day. If you suffer from food allergies, food sensitivities, or pollen food allergy syndrome we are here to help improve your life by preventing unwanted food-related symptoms that have been so troublesome. Black & Kletz Allergy is devoted to providing the highest quality allergy care in a comfortable, compassionate, and professional environment.

Allergies to Tree Pollen

This year so far it has been much warmer than usual for Winter. Typically in the Washington, DC Northern Virginia, and Maryland metropolitan area, trees begin to pollinate in March. Over the last few years however, tree pollination began in February. This year, we have seen tree pollen in the air in January and February! For many individuals, tree pollen is the cause for terrible hay fever (i.e., allergic rhinitis) symptoms. In addition to hay fever, tree pollen can and does exacerbate asthma symptoms in those who are allergic to trees and also have asthma. Some of the first trees to pollinate in this area include cedar, maple, elm, alder, birch, and poplar.  Later in the Spring season, the principal tree that causes difficulties for people with tree pollen allergies is the oak tree.  Other trees that pollinate during this later time frame include walnut, hickory, and pine.

Interestingly, it is not the flowering trees that generally cause allergy symptoms. Most people think that in the Washington, DC area that the cherry blossoms are a major cause of allergies. In fact, cherry blossoms rarely cause allergies but they tend to bloom when other trees that cause allergies in the area pollinate. People either suffer from tree pollen allergies or see others suffer from tree pollen allergies and associate the blooming of the cherry trees with allergies. It is the “ugly” non-flowering trees that tend to cause allergy symptoms. Why, you may ask? Flowering trees (e.g., dogwood trees, cherry trees, redbud trees, magnolia trees) are pretty for a reason. The pollen from flowering trees is relatively heavy. Since the pollen is heavy, it needs the help of bees to help cross-pollinate. The abdomen of the bees land on the pollen of a flower after being attracted to the flower. The bees then land on another flower and the pollen from their abdomen cross-pollinates the other flowers. Non-flowering trees (e.g., maple trees, oak trees, birch trees, hickory trees), on the other hand, have much lighter pollen which is easily wind dispersed. They cross-pollinate by releasing their pollen into the air and having it blow to other trees. It is the result of this wind dispersal that leads to people becoming allergic to tree pollen. Individuals inhale the tree pollen and they may become sensitized to the pollen which manifests itself by the classic allergy or asthma symptoms.

What are the allergy symptoms for tree pollen allergies? The classic symptoms may include runny nose, nasal congestion, post-nasal drip, itchy nose, itchy throat, itchy roof of mouth, sneezing, sinus congestion, sinus headaches, itchy eyes, watery eyes, puffy eyes, dark circles under the eyes, and/or redness of the eyes. Other less common symptoms may include fatigue, sore throat, snoring, hoarseness, itchy skin, coughing, and/or feeling like you are in a “fog.” Tree pollen can also trigger asthma or even cause asthma symptoms in those who have never had asthma or asthma symptoms. The classic symptoms of asthma may include chest tightness, wheezing, coughing, and/or shortness of breath.

The diagnosis of tree pollen allergies begins with a comprehensive history and physical examination by a board certified allergist. Allergy testing by skin testing or blood testing is often performed in order to determine if the allergies are caused by tree pollens or other allergens such as molds, grasses, weeds, and/or dust mites. In addition to finding out what the patient is allergic to, the degree of the allergy can be ascertained by the severity of the reaction on skin testing or the degree of positivity on the blood tests.

The management of tree pollen allergies begins with avoidance or prevention, if at all possible. Individuals are encouraged to monitor the pollen counts which can be tracked on the top right of our homepage by clicking Today’s Pollen Count.  In one’s car, it is advisable to keep one’s windows and sunroof closed and to turn on the air conditioner and change the air filters regularly (about once a month).  Use the re-circulate feature in the car so that the air is not coming into the vehicle from the outside.  Choose an automobile that has a filter in its air conditioning unit, if possible.  Stay indoors wherever possible when the pollen count is high (i.e., generally on dry warmer days).  It is important to realize that rain washes away pollen from the air causing pollen counts to be lower on wet cooler days.  Since pollen is released in the early mornings, try to avoid exercising during this time. If a person goes outdoors, shower, wash one’s hair, and change one’s clothing before returning home in order to lessen one’s pollen exposure.  Avoid drying clothes outdoors when the pollen count is elevated.  Avoid yard work and mowing lawns, if possible.  If one needs to do yard work, wear a filtration face mask in order to reduce exposure to the tree pollen.  Avoid contact lenses which may trap pollen in one’s eyes.  Wash one’s pets regularly and avoid close contact with a pet that goes outside during the pollen season since pets carry tree pollen on their coats.

The treatment of tree pollen allergies varies depending on how severe the patient’s symptoms are and if and how the trees affect and alter the desired lifestyle of the individual. Some people do not mind staying indoors in the Spring where others want to participate in outdoor activities such as golfing, jogging, baseball, etc. Oral antihistamines [Clarinex (desloratadine), Allegra (fexofenadine), Zyrtec (cetirizine), Claritin (loratadine), Xyzal (levocetirizine)] and nasal corticosteroids [Flonase (fluticasone), Nasonex (mometasone), Nasacort AQ (triamcinolone), Rhinocort Aqua (budesonide)] are usually the first medications prescribed in individuals that have tree pollen allergies. Oral decongestants [Sudafed (pseudoephedrine)] may be useful in certain patients with nasal congestion assuming there is no contraindication for using them such as hypertension. Other medications may be used and some of these may include oral leukotriene antagonists [i.e., Singulair (monteleukast)], nasal antihistamines [i.e., Patanase (olopatadine), Astelin (azalastine)], nasal anticholinergics [i.e., Atrovent (ipratropium bromide)], and various eye drops. For the treatment of asthma induced by tree pollen, inhaled corticosteroids, leukotriene antagonists, long acting beta 2 agonists, and/or short acting beta 2 agonists are utilized.

The board certified allergists at Black & Kletz Allergy have 3 offices in the Washington, DC, Northern Virginia, and Maryland metropolitan area and treat both children and adults with tree pollen allergies. We have offices in Washington, DC, McLean, VA (Tysons Corner, VA), and Manassas, VA. Black & Kletz Allergy offers on-site parking at each of their 3 office locations and the Washington, DC and McLean, VA offices are also Metro accessible. There is a free shuttle that runs between our McLean, VA office and the Spring Hill metro station on the silver line. To make an appointment, please call our office or you can click Request an Appointment and we will respond within 24 hours on the next business day. Black & Kletz Allergy has been serving the asthma and allergy needs of the Washington, DC metro area community for more than 5 decades and we strive to offer the highest quality allergy and asthma care in a compassionate and specialized environment.

Respiratory Syncytial Virus (RSV)

Nearly all children get infected with respiratory syncytial virus (RSV), a highly contagious virus, by their second birthday. RSV has a seasonal predilection, usually from December to March every year. In most instances, it causes mild “cold-like” symptoms and resolves without complications in approximately 1-2 weeks.

Although most cases get better and resolve on their own, respiratory syncytial virus can sometimes lead to severe illness requiring visits to the emergency room. In some cases, hospitalization may be required. The incidence of severe illness due to RSV is especially high during the Winters in the U.S. Surging RSV infections in conjunction with the rise in flu and COVID-19 infections has been termed the “tripledemic.”

RSV is especially severe in very young children and adults over 65 years of age. Predisposing factors to severe RSV infections may also include underlying chronic lung and/or heart conditions as well as having a compromised immune system.

Respiratory syncytial virus is the most common cause of bronchiolitis (i.e., inflammation of the small airways in the lungs) in children younger than 1 year of age. RSV causes approximately 60,000 hospitalizations among children under the age of 5 annually. RSV infection is estimated to cause approximately 15,000 annual deaths in the U.S. in adults over the age of 65. Respiratory syncytial virus is the leading cause of lower respiratory tract infection in children and is a common cause of wheezing in infants and young children. Studies suggest that a severe RSV infection early in childhood is linked to development of asthma later in life.

The infection of respiratory syncytial virus spreads from person to person primarily by contact with respiratory secretions and to a lesser extent by aerosol and droplets. RSV can survive for many hours on hard surfaces such as tables and door handles and lives on soft surfaces such as tissues and hands for shorter amounts of time.

Symptoms:
The symptoms of respiratory syncytial virus usually begin 2 to 3 days after contact with the virus. The initial symptoms usually include nasal congestion and runny nose with clear mucus secretions, an itchy throat and a dry cough. Children can also experience mild fevers, poor appetite, and reduced physical activity.

For babies, thick mucus can clog up the nose and small air passages in the lungs, making it difficult for them to breathe. Narrowed bronchial tubes may also cause wheezing in addition to a severe cough. Respiratory distress requires hospitalization where supplemental oxygen and inhaled medications can be administered.

Older adults, especially those with asthma, chronic obstructive pulmonary disease (COPD), heart diseases, and/or diabetes mellitus can develop pneumonia from an RSV infection. The virus can also aggravate their underlying lung conditions requiring emergency treatment.

Diagnosis:
The diagnosis of RSV is suspected by clinical presentation and can be confirmed by laboratory tests using a nasal mucus swab. Imaging of the lungs may also be needed in order to evaluate the severity of the condition.

Treatment:
The treatment of respiratory syncytial virus is only supportive care in most instances as there is no specific medication available. For young children, nasal saline with gentle suctioning and a cool-mist humidifier may help with their breathing.

In severe cases, intravenous (IV) fluids may need to be given in order to treat dehydration. Oxygen supplementation may be needed to relieve any breathing difficulty.

A medication known as Synagis (palivizumab) is sometimes prescribed in order to minimize or prevent serious RSV disease among high-risk infants and children less than 2 years of age. This drug does not improve symptoms for children already suffering from RSV, nor does it prevent infection with RSV.

Prevention:
People infected with RSV are usually contagious for 3 to 8 days and may become contagious 1 to 2 days before they begin showing signs of the illness.

One of the most effective ways to prevent an RSV infection is to practice good hand hygiene. Frequent hand washing, covering sneezes and coughs, and avoiding direct contact with unclean surfaces are very helpful in minimizing the spread of respiratory syncytial virus.

Effective vaccines and therapeutics to prevent and treat RSV infections are in active development. The research into developing an RSV vaccine began in the 1960’s and this year (2023) RSV vaccines should be on the market. The pharmaceutical companies Pfizer, GSK, and Moderna have been working on such a vaccine and are all close to the final product. Pfizer and GSK announced promising Phase III results in 2022 and they are now both awaiting regulatory approval for the vaccine.

The board certified allergists at Black & Kletz Allergy see both adult and pediatric patients and have over 5 decades of experience in the field of allergy, asthma, and immunology. Black & Kletz Allergy has 3 convenient locations with on-site parking located in Washington, DC, McLean, VA (Tysons Corner, VA), and Manassas, VA. The Washington, DC and McLean, VA offices are Metro accessible and we offer a free shuttle that runs between the McLean, VA office and the Spring Hill metro station on the silver line. To schedule an appointment, please call any of our offices or you may click Request an Appointment and we will respond within 24 hours by the next business day. We have been servicing the greater Washington, DC metropolitan area for over 50 years and we look forward to providing you with the highest state-of-the-art allergy care in a friendly and relaxed environment.

Lipid Transfer Protein Allergy

Many fruits and vegetables contain substances called lipid transfer proteins (LPT’s). They are usually present in the skin and seeds of these foods. Lipid transfer proteins are also found in various nuts and some cereals. In the plant, the purpose of the lipid transfer proteins is to move the lipid molecules so the plants develop and maintain their internal and external structures.

Individuals can become sensitized to the lipid transfer proteins. As a result, people can have allergic reactions to them when exposed in the foods we consume. When this occurs, it is called lipid transfer protein allergy. When an individual is allergic to many foods containing lipid transfer proteins, it can be said that that person has lipid transfer protein syndrome.  The most common plant foods triggering these reactions include apples, grapes, peanuts, almonds, hazelnuts, walnuts, tomatoes, and dried fruit. Other foods that may also cause symptoms may include mustard seeds, sunflower seeds, chestnut, peaches, strawberry, kiwi, orange, tangerine, pear, banana, lemon, apricot, plum, raspberry, pomegranate, cherry, barley, lettuce, cabbage, corn, mulberry, asparagus, green beans, pea, celery, wheat, durum wheat, lentils, and lupin. Other foods that are known to contain lipid transfer proteins include broccoli, onion, beetroot, parsley, eggplant, parsnip, butter beans, fennel, millet, goji berry, quinces, grapefruit, blueberry, and figs.

Lipid transfer proteins are resistant to heat and to the acid in our digestive tract. This heat and acid resistance make it so that individuals can react to even well-cooked, dried, raw, and/or canned foods. For example, if someone is sensitized to the lipid transfer proteins in a grape, that person should avoid all grape-containing foods such as grape juice, wine, and raisins.

This condition is more common in adults as well as people living in Mediterranean countries. In fact, lipid transfer protein allergy is the most frequent cause of food allergy in southern Europe. It is however interesting to note that lipid transfer protein allergy has been increasingly recognized in other parts of the world.

SYMPTOMS: The symptoms of lipid transfer protein allergy usually begin within 10 to 30 minutes after eating the offending food. The symptoms may include the following:

  • Itching of the mouth and/or throat
  • Runny nose
  • Nasal congestion
  • Sneezing
  • Abdominal pain
  • Nausea and/or vomiting
  • Skin rashes [i.e., hives (urticaria)]
  • Swelling of the lips, tongue, and/or throat (i.e., angioedema)
  • Wheezing
  • Shortness of breath
  • Drop in blood pressure
  • Dizziness/Lightheadedness
  • Anaphylaxis

Some contributing factors of an allergic reaction due to eating a suspected food with lipid transfer proteins may include physical exertion, alcohol consumption, and certain medications [e.g., nonsteroidal anti-inflammatory medications (NSAID’s) such as ibuprofen or naproxen]. These factors also may delay the onset of the allergic symptoms where the allergic reaction begins after the typical 10 to 30 minute window. Exercise, alcohol, and NSAID’s can also increase the severity of the allergic reaction. There are even cases where someone can eat a plant-based food that contains lipid transfer proteins and has no allergic reaction but when combined with exercise, alcohol consumption, and/or NSAID exposure, that individual may experience an allergic reaction.

DIAGNOSIS: The diagnosis of this condition involves a comprehensive history and physical examination. Special emphasis should be targeted towards getting a detailed record of the patient’s food intake. Maintaining food and symptom diaries are extremely useful in helping to establish the diagnosis. The food and symptom diaries should be supplemented with allergy skin prick testing with suspected food antigens and/or laboratory evaluation when needed.

DIFFERENTIAL DIAGNOSIS: The differential diagnosis includes other food-induced allergic reactions such as pollen-food allergy syndrome (i.e., oral allergy syndrome) and food-dependent exercise-induced urticaria/anaphylaxis (FDEIA).

TREATMENT: Once the diagnosis is confirmed, avoidance of all forms of the plant food including raw, cooked, and processed forms of the food is essential in order to minimize the risk of severe reactions.

Individuals diagnosed with lipid transfer protein allergy will also be prescribed a self-injectable epinephrine device (e.g., EpiPen, Auvi-Q, Adrenaclick) which is to be used in the case of a systemic reaction following an inadvertent exposure to the offending food. It should be stressed that if an individual uses a self-injectable epinephrine device, that person should go immediately to the closest emergency room.

The board certified allergy specialists at Black & Kletz Allergy will promptly respond to any questions you may have regarding food allergies or any other allergic or immunologic disorder. Black & Kletz Allergy has been treating food allergies for many years and we have offices in Washington, DC, McLean, VA (Tysons Corner, VA), and Manassas, VA. We have been serving the Washington, DC, Northern Virginia, and Maryland metropolitan area for over 50 years and treat both pediatric and adult patients. All 3 offices at Black & Kletz Allergy offer on-site parking and the Washington, DC and McLean, VA offices are Metro accessible. There is a free shuttle that runs between our McLean, VA office and the Spring Hill metro station on the silver line. If you are concerned that you may have a food allergy or sensitivity or any other allergic or immunologic condition such as allergic rhinitis (i.e., hay fever), asthma, sinus disease, medication allergies, flying insect allergies, or hives (i.e., urticaria), please call us to schedule an appointment. You may also click Request an Appointment and we will respond within 24 hours by the next business day. At Black & Kletz Allergy, we strive to improve the quality of life in allergic individuals using state-of-the-art medicine in a professional and compassionate setting.

Update on Dog, Cat, and Other Pet Allergies

In the U.S., dogs are the most common pets. According to the American Veterinary Medical Association, approximately 77 million pet dogs are living in the country spread around roughly 49 million homes. This means that each dog-owning household has an average of 1.5 dogs. The most common breed of dog is the Labrador Retriever. The second most common pets are cats. According to the American Veterinary Medical Association, there are about 32 million homes in the U.S. with cats comprising of approximately 59 million cats in total. Thus, the average cat-owning home has an average of 1.8 cats. The most common breed of cat is the Ragdoll. Fish, birds (e.g., parakeets, cockatiels, parrots), reptiles (e.g., lizards, turtles, snakes, geckos), rabbits, poultry (e.g., chickens, ducks, turkeys, geese), hamsters, guinea pigs, and ferrets round off the top 10 most common pets in the U.S. in that order. Overall, about 70% of homes have at least one pet. The number of pet-owning households continues to rise compared with ownership in the past.

It should also be noted that approximately 4 million households’ own horses. Horses do not normally live in people’s homes, but they still may be rather allergenic. In recent years, it has become fashionable to own miniature horses, which in some cases, do live in their owner’s home. Living with a horse in one’s house is probably not a good idea, but for those who are allergic to horses, it is especially ill-advised.

Whereas Wyoming is the top state for pet ownership at 71%, Idaho residents have the greatest number of dogs owners at approximately 59%. In contrast, Washington, DC has the least number of pet-owning households at 39%. Of note, 46% of Vermont residents have cats in their home making it the highest in the nation.

In general, a pet allergy is caused by an allergic reaction to specific proteins that are only found on the pet in question. The classic symptoms of pet allergies may include sneezing, runny nose, nasal congestion, post-nasal drip, sinus congestion, itchy nose, itchy throat, itchy eyes, watery eyes, red eyes, chest tightness, coughing, wheezing, and/or shortness of breath. The diagnosis of a pet allergy is done by taking a comprehensive history and physical examination of the patient in combination with allergy testing (i.e., blood tests, skin tests). Once the diagnosis is made, the best approach is prevention. If an individual can avoid being exposed to the pet, no other treatment is generally needed. If they must be exposed or refuse to avoid the animal, then the treatment may consist of oral antihistamines, oral, decongestants, leukotriene antagonists, nasal corticosteroids, nasal antihistamines, nasal anticholinergics, ocular antihistamines, ocular mast cell stabilizers, inhaled bronchodilators, inhaled mast cell stabilizers, and/or inhaled corticosteroids. For those who decide to live with their pet, allergy shots (allergy immunotherapy, allergy injections, allergy desensitization, allergy hyposensitization) may be indicated. Allergy injections are very effective as they work in 80-85% of individuals who take them. They have been given to patients for over 100 years and they are generally given for a period of 3-5 years.

People who are allergic to dogs usually have a reaction to the major protein called “Can f 1,” which is found on dogs. Specifically, the dander of dogs contains this major dog protein, Can f 1. It should be noted that the furry hair of a dog, which is not allergenic, may also transport other allergens (i.e., dust, pollens) to sensitive allergic individuals causing them to be exposed to more dust and pollens.  The dander of a dog can stick to an individual’s clothing, bedding, carpeting, etc., but with less affinity.  In addition to the dog’s dander, the Can f 1 protein is also found in a dog’s saliva and urine.  It is important to note that a dog allergy will cause perennial symptoms, unlike pollen allergies which generally affects individuals in certain seasons.

Individuals with cat allergies have a very similar situation to those with dog allergies, however, the major proteins responsible for the allergic reaction are named “Fel d 1” and “Fel d 4.” These proteins are found in the sebaceous glands of the skin (i.e., dander), the saliva, and the urine of cats. The dander of a cat tends to “stick” to things such as walls, bedding, carpeting, clothes, etc. Even with professional cleaning, it still takes a long time (i.e., up to several months) for the levels of cat protein to decrease to tolerable levels. Thus, removing a cat from one’s home for a few weeks is not long enough to determine if the cat is the problem. One misconception that is quite common is that there are “hypoallergenic cats.”  All cats have the capacity to induce allergic symptoms to cat-sensitive individuals. Some patients feel that they can tolerate short-haired cats better than long-haired cats, but studies do not support this theory. Brushing and bathing your cat regularly will however reduce the cat protein levels that cause allergic symptoms and of course is advisable.

Bird and rodent allergies are similar to other pet allergies except that in addition to the dander, the proteins responsible for the allergic reaction are also found in the urine, fecal, and feather particulates in birds and in the urine, saliva, and fecal droppings in rodents (e.g., hamsters, guinea pigs, mice, rats, gerbils, chinchillas). It is important to point out that in addition to allergies, both birds and rodents pose another threat to one’s health. Exposure to birds can cause more than 60 infections and diseases. Some of these may include avian flu, avian tuberculosis, psittacosis, salmonellosis, allergic alveolitis, campylobacteriosis, giardiasis, Newcastle disease, histoplasmosis, and cryptosporidiosis. Exposure to rodents (e.g., mice, rats) can cause many diseases as well such as the hantavirus pulmonary syndrome (HPS), tularemia, leptospirosis, salmonellosis, bubonic plague, rat-bite fever (RBF), Lassa fever, and lymphocytic choriomeningitis.

Allergies to reptiles are not common.  There have been reports of allergies to snakes, and of course there is always the possibility of an allergic reaction to the venom of certain snakes. There have also been reported cases of allergies to various reptiles, particularly iguanas. In addition to the typical allergy symptoms that occur with other pets, there seems to be more skin irritation with reptiles than with other pets.

Horse allergies are not that uncommon.  Individuals that are allergic to horses typically have similar symptoms as people with cat and/or dog allergies. The dander is the most common way in which horses cause allergic symptoms in humans.  The horse’s saliva, urine, and the fecal material dropped by horse mites are other ways that people are exposed to the allergenic proteins of horses. There is an increased incidence of horse allergy in some individuals that have cat and/or dog allergies due to a common protein that is shared between all 3 animals.

The board certified allergists at Black & Kletz Allergy have been diagnosing and treating pet allergies in both adults and children in the Washington, DC, Northern Virginia, and Maryland metropolitan area for more than 50 years. Black & Kletz Allergy has 3 offices in the Washington, DC metropolitan area with locations in Washington, DC, McLean, VA (Tysons Corner, VA), and Manassas, VA. All of our offices have on-site parking and the Washington, DC and McLean, VA offices are Metro accessible. We offer a free shuttle that runs between our McLean, VA office and the Spring Hill metro station on the silver line. If you suffer from a pet allergy or are not sure if you do, please call us to and make an appointment at one of our conveniently located offices. Alternatively, you may click Request an Appointment and we will respond within 24 hours by the next business day. The allergy specialists at Black & Kletz Allergy are confident that we will be able to help you with your furry friends.